Commentary: Suggestions on antidepressant related research
The insula is a cortical structure located in the brain. The insula seems to be involved in various cognitive functions such as sensory perception, metacognition and self-awareness among others. Evidence suggest that the insula also plays a role in depression. In this commentary article possible limitations are discussed concerning research done by Geugies and collaborators (2019) related to the insula in conjunction with antidepressant therapy. Opposite findings are presented, that were reported in an article written by Lui and collaborators (2011) and suggestions are made for the replication of the Geugies and collaborators (2019) study in more specific controlled trials.
Keywords: depression, insula, treatment resistance, fMRI, antidepressants
