Cyclosporine A Mycosynthesis and Its Clinical Significance

Tolypocladium inflatum is a fungus at first isolated from Norwegian soil and has for quite some time been of interest in biotechnology because of its capability toproduce non-cytotoxic, normal 11 amino acids and the cyclic peptide cyclosporine A. cyclosporine A is an immunosuppressant narrow spectrum antifungal peptide and is utilized in heart, liver, and kidney transplantations.

KEYWORDS:Immunosuppressant;Thioesters; Autoimmune;Transplantation;Interleukin