SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY OF Ni (II), COMPLEX DERIVED FROM CLOXACILLIN AND CEPHALEXIN
A new metal complex of Ni (II) with cloxacillin and cephalexin (mixed ligands), [Ni (Clox) (Cep)Cl2] was synthesized in 1:1:1 ratio. The complex was characterized for its physicochemical properties and spectral studies. From the IR and electronic spectral studies, the spectra of the complex were found to be different from that of the ligands suggesting the formation of coordination compound. The ligands coordinated with the Ni (II) ion through the carbonyl group (C=O) of the carboxylate and the carboxyl groups of the amide in both the cloxacillin and cephalexin antibiotics. This has made the complex to assume octahedral geometry. The complex has shown good antibacterial activity. It is therefore recommended among others that; pharmaceutical companies and other researchers should exploit these findings to process the complex further to produce potent antimicrobial drugs.
Keywords: Ligands, Complex, Synthesis, Antibacterial activity, cloxacillin, cephalexin
