Bibliometric Review of Acute Myocardial Infarction Biomarker Studies Between 2015 and 2025
Background: Acute myocardial infarction (AMI) remains one of the leading causes of mortality and morbidity worldwide. Early diagnosis and prompt treatment are essential for improving clinical outcomes. Biomarkers play a critical role in the diagnosis, prognosis, and management of AMI. In recent years, increasing attention has been directed toward novel inflammatory and molecular biomarkers in addition to traditional cardiac biomarkers.
Objective: The aim of this study was to perform a bibliometric analysis of scientific publications related to biomarkers in acute myocardial infarction published between 2015 and 2025 and to evaluate global research trends, influential countries, major research themes, and emerging topics in this field.
Methods: A comprehensive literature search was conducted using the Web of Science Core Collection, Scopus, and PubMed databases. Publications related to AMI biomarkers published between 2015 and 2025 were included. Bibliometric indicators including publication trends, citation analysis, country productivity, keyword co-occurrence, and collaboration networks were analyzed using VOSviewer and the Bibliometrix package in R software.
Results: The analysis demonstrated a substantial increase in the number of publications and citations over the study period, particularly after 2020. Cardiac troponin I/T remained the most frequently investigated biomarker, followed by CK-MB, BNP/NT-proBNP, CRP, IL-6, galectin-3, microRNAs, and semaphorins. The United States and China were identified as the leading contributors to scientific production. Keyword analysis revealed that “high-sensitivity troponin,” “inflammation,” “prognosis,” and “precision medicine” were among the most prominent research themes. Emerging trends included molecular biomarkers, artificial intelligence-supported diagnostics, and personalized medicine approaches.
Conclusion: Biomarker research in AMI has expanded significantly over the past decade. While traditional biomarkers continue to play a central role in clinical diagnosis, emerging inflammatory and molecular biomarkers are gaining increasing scientific interest. Bibliometric findings suggest that future AMI research will increasingly focus on precision medicine and multi-marker diagnostic strategies.
Keywords: Acute myocardial infarction, biomarkers, bibliometric analysis, troponin, inflammation, cardiovascular disease, precision medicine, microRNA
