The solvent extract of Picralima nitida seeds exerts ameliorative effects in alloxan-induced diabetes in wistar rats
The result shows that crude seed extract of Picralima. nitida contains Alkaloid, Saponins, Flavonoid and cardiac glycosides. At three- and four-hours post administration of chloroform extract, there was a decrease in blood glucose levels compared to the positive and standard controls. At four hours post administration of diethyl extract of PN, there was no significant difference in the blood glucose level when compared to the positive control. there was a decrease in the blood glucose levels in the positive control groups at two, three- and four-hours post administration of ethyl acetate extract, however, there was no difference (P>0.05) in the standard controls at one, two, three- and four-hours post administration. At three- and four-hours post administration, the blood glucose was low when compared to the positive control and was still high when compared to negative control. However, there was no significant difference when compared to the standard control. At one to three hours post administration of methanol extract of PN, the blood glucose levels were high when compared to the negative control. However, there was no significant difference when compared to the positive and standard controls. There was a significant (P<0.05) increase in the High-Density Lipoprotein (HDL), value and a significant decrease in the Low-Density Lipoprotein (LDL) in alloxan induced rat on chloroform extract of PN when compared to the positive control. There was a (P<0.05) increase in the High-Density Lipoprotein (HDL) value and a significant decrease in the Low-Density Lipoprotein (LDL) in alloxan treated rats on ethyl acetate extract compared to the positive control. However, there was no (P>0.05) difference in total protein, total cholesterol and triglyceride values when compared to the Control groups (Table 3). There was a significant (P<0.05) increase in the total cholesterol and triglyceride in alloxan treated rats administered diethyl extract compared to the negative control. However, there was a significant decrease in cholesterol values when compared to the positive and standard controls. There was a significant increase in HDL value and decrease in LDL value when compared to the positive control. There was no difference (P>0.05) in the Total Protein value when compared to the control groups (Table 3). There was a significant increase in the total cholesterol values of alloxan treated rats on acetate extract when compared to the negative and standard controls. There was a decrease (P<0.05) in the Triglyceride value when compared to both positive and standard controls. There was a significant increase in the HDL values and decrease in the LDL values when compared to the positive control group. There was a significant decrease in the Total cholesterol, Triglyceride and LDL in rats administerd methanolic extract when compared to the positive control. There was also a significant decrease in the Triglyceride value when compared to the standard control
